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Human DNA ligases may also be prospect drug targets for adjuvant cancer chemotherapy, predicated on potentiating the consequences of DNA-harming antineoplastics by transiently impeding DNA restore in tumor cells.
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The zinc-finger module plays a structural position in bridging the OB and HhH domains. Domain Ia helps make no contacts Along with the DNA duplex, in keeping with its dispensability for catalysis of strand closure on an AppDNA substrate. (No electron density was observed for the C-terminal BRCT domain.)